create default variables

IS it possible to create a variable in powershell that is static.
Even when you close powershell?

You could use environment variables or you could add it to your all users psprofile.

@ Olaf soyk

Could you explain?

How to create and modify environment variables is explained here: Creating and Modifying Environment Variables.

And how to modify your Powershell profile or the systems Powershell profile you can find like this: Get-Help about_profiles