The answer to your question is, “It Depends”. You can definitely do the work through WMI with PowerShell, You can also do the work with regedit.exe, reg.exe, remote-item, etc., etc., etc. through PowerShell. The best choice will depend on requirements and skill set. If this is a one time use scenario and just need a solution, that’s easy to just knock out, regedit.exe or reg.exe may be the best choice. If you need to hit remote machine, but don’t know how to use WMI, or remove-item, reg.exe may be the best choice. If you are well versed in WMI and need something that is repeatable, that may be your best choice. If your choice requires the best performance, then you will need to do some performance testing with the different options to see which process is best for your environment. measure-command is available in PowerShell to help you do that performance testing.